Academy City, au Japon, est à la pointe de la science. En plus d'être en avance de trente ans sur le monde technologiquement, plus des trois quarts de la population de cette ville particulière sont des étudiants qui développent leurs capacités psychiques en tant qu'espers dans divers établissements. Parmi ces étudiants se trouve Touma Kamijou, un lycéen avec le rang psychique le plus bas, zéro, mais avec un pouvoir mystérieux qu'aucun scientifique ne peut comprendre : « Imagine Breaker », qui lui permet d'annuler d'autres capacités surnaturelles. Cela n'affecte pourtant pas le moins du monde la vie de Kamijou, qui joue son rôle d'adolescent ordinaire ; du moins, jusqu'à ce qu'il rencontre l'étrange Index Librorum Prohibitorum, une jeune fille qui a mémorisé l'intégralité des grimoires interdits, et qu'une organisation dangereuse traque Index. Avec plusieurs magiciens cherchant à faire du mal à la jeune fille, Kamijou défendra sa nouvelle compagne à tout prix alors qu'il découvre un étrange nouveau royaume du surnaturel. [Écrit par MAL Rewrite]

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